Corrections: The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

Table 1. Numeric Values of Input Quantities of the Model for the Reference State The data are grouped into concentrations of pathway components, dissociation constants of protein complexes, concentration ratios, fl uxes and fl ux ratios, and characteristic times of selected processes. Experimental evidence for these data is discussed in the text. From these data, the following rates and rate constants are calculated: ν12 = 0.42 nM • min (rate of β-catenin synthesis), ν14 = 8.2 • 10 • nM • min (rate of axin synthesis), k4 = 0.27 min, k5 = 0.13 min, k6 = 9.1 • 10 nM • min, k–6 = 0.91 • nM • min, k9 = 210 min, k10 = 210 min, k11 = 0.42 min, k13 = 2.6 • 10 –4 min, k15 = 0.17 • min. See Table S2, found at http://dx.doi.org/10.1371/journal.pbio.0000010.t002, for more precise numbers used in the calculations. Bold: Measured values, Italics: Estimated values. DOI: 10.1371/journal.pbio.0000010.t001